nashville titans could sial to their game by cruising up the (10 blanks) River to its confluence with the (9 blanks) River then on to the (4 blanks) River.
I did not know that Nashville was in the Middle East, nor even had a team called the Titans. Your ten-letter word may be Cumberland. The four-letter word may be Ohio. The nine-letter word may be Tennessee. What does this question have to do with Economics?
The trip described would be down river, not up river.