1. DAG activates _______.In turn kinase_____ its own substrate
a. PKA, phosphatates
b. PKA, phosphorylates
c. PKC, phosphates
d. PKC,phosphorylates
I think the right answer is d, please check
Since this is not my area of expertise, I searched Google under the key words "DAG PKC phos" to get these possible sources:
http://www.jbc.org/cgi/reprint/277/1/645.pdf
http://opbs.okstate.edu/~Blair/Bioch4113/Signal%20Transduction%20-%201998.htm
http://content.karger.com/ProdukteDB/produkte.asp?Aktion=ShowPDF&ArtikelNr=93042&ProduktNr=224154&Ausgabe=231942&filename=93042.pdf
In the future, you can do similar searches yourself to get answers more quickly.
I hope this helps. Thanks for asking.
The correct answer to the question is d. DAG activates PKC, and in turn, PKC phosphorylates its own substrate. DAG, which stands for diacylglycerol, acts as a secondary messenger in signal transduction pathways. When a signaling molecule binds to its receptor on the cell membrane, it triggers the activation of phospholipase C (PLC), which cleaves phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol trisphosphate (IP3) and DAG. IP3 then releases calcium ions from intracellular stores, while DAG remains in the membrane and activates PKC.
PKC, or protein kinase C, is a family of kinases that play a crucial role in various cellular processes. When activated by DAG, PKC translocates to the cell membrane where it phosphorylates its target substrate proteins. Phosphorylation is a post-translational modification that often results in changes to protein conformation, activity, or interactions with other molecules. Therefore, the activation of PKC by DAG ultimately leads to the phosphorylation of its own substrate proteins.
To find the answer, I recommend referring to reliable sources such as research articles or textbooks on signal transduction pathways and protein kinases. These sources will provide more detailed information on the topic. Additionally, using specific search terms like "DAG PKC phosphorylation" can help you find relevant information more efficiently.