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Posted by on Tuesday, September 2, 2014 at 12:25pm.

PCSK9, a protease that regulates the level of LDL receptors, is a new target for lowering circulating levels of LDL. Excess PCSK9 leads to a decrease in LDL receptor levels. Which one of the following tools would you use in mice to model a potential therapy for humans with familial hypercholesterolemia?

A)RNAi targeting PCSK9 in mice

B)add an extra copy of the PCSK9 gene fused to the GFP coding sequence add an extra copy of the gene encoding PCSK9
C)a microarray comparing mRNA levels in a mouse heterozygous for a loss-of-function PCSK9 allele to the wild-type mouse
D)a SNP chip using a mouse heterozygous for a loss-of-function PCSK9 allele

  • Biology - , Wednesday, September 3, 2014 at 10:22am

    UNfortunately its not b, a ruled out, so it should be c or d........

  • Biology - , Thursday, September 4, 2014 at 10:43pm

    Why is (A) ruled out? That looks the best bet to me

  • Biology - , Monday, January 9, 2017 at 8:54pm

    what is the answer??

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