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January 29, 2015

Posted by **Rupal** on Thursday, August 15, 2013 at 11:58am.

This table displays results from a prospective cohort study evaluating meat intake and mortality. The table displays hazard ratios for mortality by quintile of red meat intake.

Table 2. Multivariate Analysis for Red, White, and Processed Meat Intake and Total and Cause-Specific Mortality in Men in the National Institutes of Health-AARP Diet and Health Studya

Quintile

Mortality in Men (n=322263) Q1 Q2 Q3 Q4 Q5 P Value for Trend

Red Meat Intakeb

All mortality

Deaths 6437 7835 9366 10988 13350

Basic modelc 1 [Ref.] 1.07 (1.03-1.10) 1.17 (1.13-1.21) 1.27 (1.23-1.31) 1.48 (1.43-1.52) <.001

Adjusted modeld 1 [Ref.] 1.06 (1.03-1.10) 1.14 (1.10-1.18) 1.21 (1.17-1.25) 1.31 (1.27-1.35) <.001

Cancer mortality

Deaths 2136 2701 3309 3839 4448

Basic modelc 1 [Ref.] 1.10 (1.04-1.17) 1.23 (1.16-1.29) 1.31 (1.24-1.39) 1.44 (1.37-1.52) <.001

Adjusted modeld 1 [Ref.] 1.05 (0.99-1.11) 1.13 (1.07-1.20) 1.18 (1.12-1.25) 1.22 (1.16-1.29) <.001

CVD mortality

Deaths 1997 2304 2703 3256 3961

Basic modelc 1 [Ref.] 1.02 (0.96-1.08) 1.10 (1.04-1.17) 1.24 (1.17-1.31) 1.44 (1.37-1.52) <.001

Adjusted modeld 1 [Ref.] 0.99 (0.96-1.09) 1.08 (1.02-1.15) 1.18 (1.12-1.26) 1.27 (1.20-1.35) <.001

Mortality from injuries and sudden deaths

Deaths 184 216 228 280 343

Basic modelc 1 [Ref.] 1.02 (0.84-1.24) 0.97 (0.80-1.18) 1.09 (0.90-1.31) 1.24 (1.03-1.49) .01

Adjusted modeld 1 [Ref.] 1.06 (0.86-1.29) 1.01 (0.83-1.24) 1.14 (0.94-1.39) 1.26 (1.04-1.54) .008

All other deaths

Deaths 1268 1636 1971 2239 2962

Basic modelc 1 [Ref.] 1.13 (1.05-1.22) 1.25 (1.17-1.35) 1.33 (1.24-1.42) 1.68 (1.57-1.80) <.001

Adjusted modeld 1 [Ref.] 1.17 (1.09-1.26) 1.28 (1.19-1.38) 1.34 (1.25-1.44) 1.58 (1.47-1.70) <.001

a: Data are given as hazard ratio (95% confidence interval) unless otherwise specified.

b: Median red meat intake based on men and women (g/1000 kcal): Q1, 9.8; Q2, 21.4; Q3, 31.3; Q4, 42.8; and Q5, 62.5.

c: Basic model: age(continuous); race (non-Hispanic white, non-Hispanic black, Hispanic/Asian/Pacific Islander/American Indian/Alaskan native, or unknown); and total energy intake (continous).

d: Adjusted model: basic model plus education (<8 years or unknown, 8-11 years, 12 years [high school], some college, or college graduate); marital status (married: yes/no); family history of cancer (yes/no) (cancer mortality only); body mass index (18.5 to <25, 25 to <30, 30 to <35, ≥35 [calculated as weight in kilograms divided by height in meters squared]); 31-level; smoking history using smoking status (never, former, current), time since quitting for former smokers, and smoking dose; frequency of vigorous physical activity (never/rarely, 1-3 times/mo, 1-2 times/wk, 3-4 times/wk, ≥5 times/wk); alcohol intake (none, 0 to <5, 5 to <15, 15 to <30, ≥40 servings/1000 kcal, vitamin supplement user (≥1 supplement/mo); fruit consumption (0 to <0.7, 0.7 to <1.2, 1.2 to <1.7, 1.7 to <2.5, ≥2.5 servings/1000kcal); and vegetable consumption (0 to <1.3, 1.3 to <1.8, 1.8 to <2.2, 2.2 to <3.0, ≥3.0 serving/1000 kcal).

Reproduced with permission from: Sinha R, Cross AJ, Graubard BI, Leitzmann MF, Schatzkin A. Meat intake and mortality: a prospective study of over half a million people. Arch Intern Med 2009;169:562-71.

QUESTION 7

7. What statistical method was used to calculate the Hazard Ratios given in the table?

Linear regression Poisson regression Cox regression Logistic regression Multiple 2x2 tables

- ju department of statistics -
**stat 270**, Monday, August 26, 2013 at 5:36amblood measureseveral weeks av.182 with sandard daviation 12.6 another petiont av.124 standad daviation 9.4 which petionts blood more variable

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