Friday
April 25, 2014

Homework Help: biology

Posted by selly on Sunday, April 7, 2013 at 9:00am.

Consider the pedigree below. This pedigree represents a family with a rare genetic disease.

Note two very important assumptions:

Individuals who marry into the family may carry a disease allele.
The disease is completelely penetrant. That is, any individual with a genotype corresponding to a disease phenotype will show the disease.

(a) Is this pedigree consistent with autosomal recessive inheritance?


Yes
No
If you chose "yes", answer questions (i) and (ii) and leave parts (iii) and (iv) blank. If you chose "no", leave parts (i) and (ii) blank and answer questions (iii) and (iv).


i) If you chose "yes" above. Drag and drop in the appropriate genotype from the options below to indicate the genotypes of all the individuals in the pedigree. You may use each of the labels below once, more than once, or not at all. Note that the upper case letter indicates the allele with the dominant phenotype.


A_AaaaAA
unanswered
ii) If you chose "yes" above. If Individuals 5 and 6 have another child, what is the probability that the child will be affected by the disease? Please give a number between 0.0 and 1.0. Use as many significant digits as you need.

unanswered
iii) If you chose "no" above. Which set or sets of individuals is inconsistent with autosomal recessive inheritance? Choose all that apply from the list below:


Individuals 1, 2, 3, and 5
Individuals 3, 4, 7, and 8
Individuals 5, 6, 9, and 10
Individuals 10, 11, 12, and 13
iv) If you chose "no" above. Can you change one individual from affected to unaffected and make this pedigree consistent with autosomal recessive inheritance? If so, give the number of that individual. If it is not possible, enter 0.

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