why it is taken 85ml of hcl for 1 lt of solvent according to I.P. while it is 43.02ml of hcl when it is calculated?
According to the Indian Pharmacopoeia (I.P.), 85 ml of hydrochloric acid (HCl) is required to prepare 1 liter (1000 ml) of solvent.
However, when you calculated it, you obtained a value of 43.02 ml of HCl.
To understand why there is a discrepancy between the two values, it's essential to consider the context and the reference being used. The Indian Pharmacopoeia (I.P.) is a compendium of quality standards for drugs and pharmaceutical substances used in India. It provides guidelines for the preparation of various solutions, including acid solutions.
When it mentions that 85 ml of HCl is required for 1 liter of solvent, it likely takes into account specific requirements or specifications for the intended application or use of the solution. These requirements can be related to the concentration, pH, or other factors unique to certain pharmaceutical processes or formulations.
In contrast, your calculated value of 43.02 ml might have been obtained using different assumptions or considerations. It's possible that you are working with a different set of guidelines, such as standardized solutions used in general laboratory practices.
To clarify the difference and resolve the discrepancy, it is necessary to review the specific instructions or context provided by the Indian Pharmacopoeia (I.P.) regarding the preparation of the solution in question or consult with a subject matter expert who can provide further insight.