Posted by rfvv on Wednesday, June 20, 2012 at 10:11am.
http://owl.english.purdue.edu/owl/resource/607/02/
The comma you used correctly in #1 is because of rule #2c here. The words "You know" are just introductory; they indicate that the speaker assumes that the listener already knows the facts in the main clause of the sentence.
Sentence 2 is stating what the speaker knows the listener knows; the only real difference is in pronunciation -- no pause after "know" as in #1.
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