Clotting disorders are common, complex and affected by a variety of medications or mechanisms. Match the mechanism to the description.
a. coumarin b. EDTA c. aspirin d. factor VIII deficiency e. tissue-plasminogen activator (TPA)
f. heparin
1.inhibits the formation pf prostaglandins from arachidonic acid
2.inhibits activation of vitamin K
3.activates antithrombin III, which inactivates thrombin
4. dissolves clots
5. removes calcium ions, which are required for calcium
6.hemophilia, a hereditary clotting disorder
a. coumarin - 2. inhibits activation of vitamin K
b. EDTA - 5. removes calcium ions, which are required for clotting
c. aspirin - 1. inhibits the formation of prostaglandins from arachidonic acid
d. factor VIII deficiency - 6. hemophilia, a hereditary clotting disorder
e. tissue-plasminogen activator (TPA) - 4. dissolves clots
f. heparin - 3. activates antithrombin III, which inactivates thrombin
To match the mechanisms to the descriptions, you can use the following information:
- Coumarin inhibits the activation of vitamin K, thus affecting the production of clotting factors.
- EDTA removes calcium ions, which are necessary for clotting.
- Aspirin inhibits the formation of prostaglandins from arachidonic acid, which ultimately affects clotting.
- Factor VIII deficiency is a hereditary clotting disorder known as hemophilia.
- Tissue-plasminogen activator (TPA) is responsible for dissolving clots in the body.
- Heparin activates antithrombin III, which inactivates thrombin, a critical enzyme involved in the clotting process.