February 25, 2017

Homework Help: Hydrogen bonding with polypeptides

Posted by Lena on Thursday, March 3, 2011 at 9:04pm.

In a polypeptide at physiologic pH, hydrogen bonding may form between which of the following?

a) side chains of leucine residue and lysine residue
b) side chains of aspartyl residue and glutamyl residue
c) terminal amino acid group and terminal carboxyl group
d) amide group in peptide bond and aspartyl group

This is my thinking. H+ is positive so it would bind to something negative. Lysine is positive so a) would be wrong. Aspartate and glutamate are negative so I'm not too sure about that one. For c) terminal amino acid group has carbon which has a positive change so H wouldn't bind there. And then d) I have no idea.

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