Where was the greatest single American loss in the war? Charleston ?
http://www.civilwarhome.com/Battles.htm
The greatest single American loss in the war refers to a significant military defeat suffered by the United States during a particular conflict. However, I need more specific information to provide a precise answer. The term "war" is quite broad, as the United States has been involved in various wars and military engagements throughout its history.
If you are referring to the American Civil War, which took place from 1861 to 1865, then Charleston, South Carolina, was not the site of the greatest single American loss. During the Civil War, major battles such as Gettysburg, Antietam, and Fredericksburg resulted in a higher number of casualties for the United States.
To identify the greatest single American loss in any war, it is necessary to provide additional details about the specific conflict or narrow down the scope of the question.