Posted by KC on .
A 100 amino acid folded protein (F) is in equilibrium with it’s unfolded (U) (or
denatured) form. Let ΔrH(std) =+347 kJ mol-1 and ΔrS(std) =-1010 J K-1 mol-1 for the equilibrium (F U) at 25℃.
(a) Calculate the concentration of protein in each form if the total
concentration of protein is 10μM.
(b)Assuming that ΔrH(std) is independent of temperature, calculate the equilibrium constant at 37℃ using the van’t Hoff equation.