posted by chris .
how were the differences important to the international state of affairs in 1450?
I wonder if it is important what differences you are thinking on? http://www.historycentral.com/dates/1400ad.html
the differences between asia, eurasia,and europe and the impact it had on the international state of affairs in 1450
Check your textbook or some of these sites.
"...and the impact it had ..."
The impact WHAT had? No one can guess what "it" is.