simplify

8{[4(q-4)+16]-[2(5q-3)+3]}

Multiply out the parentheses terms and then collect the constants and the terms proportional to "q" separately.

8{[4(q-4)+16]-[2(5q-3)+3]}
= 8{[4q- 16)+16] -[10q-6+3]}
= 32 q - 8(10q -3)
= -48q +24