Homework Help: Chemistry

Posted by Mike on Thursday, August 13, 2009 at 4:31am.

Mefenamic acid (Ponstan Forte) has a half life of 2 hours.

Naproxen has a half life of 12 to 17 hours.

Both are anti inflammatory drugs of apparently similar nature but could someone please explain the difference in half life?

Thank you

Mike

Chemistry - bobpursley, Thursday, August 13, 2009 at 9:09am
Absorbtion and breakdown are enzymatic reactions in the liver, "similar" is not good enough for many enzymes in reaction energy or speed. I would bet different enzyme pathways on breakdown.

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