Posted by Scott on Saturday, March 7, 2009 at 9:55am.
I assume that this is TLC on silica.
The more polar solvent is needed to move the more polar molecule. b) are the least polar molecules and so you would try hexane to separate them.
a) are the next polar pair, so as you say methylene chloride would be a good choice.
c) the most polar set and acetone is a good choice.
In practice you would choose a solvent and modify it you don't get a good separation you would try something else. The reason for the TLC is also important, if you are monitoring a reaction then it does not matter too much how good the separation is, provided you can see the separation. If you are using TLC to prepare a sample then you would want to make sure there is a clear separation.
You will also find that the solvent or solvent mixture will also affect the shape of the spot, so sometimes the solvent choice is a compromise.
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