what is the comparison of normal and abnormal chroasome (when the abnormal is the alexander disease)
Since this is not my area of expertise, I searched Google under the key words "alexander disease chromosome" to get these possible sources:
http://en.wikipedia.org/wiki/Alexander_disease
http://www.answers.com/topic/alexander-disease
http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=alexander
In the future, you can find the information you desire more quickly, if you use appropriate key words to do your own search. Also see http://hanlib.sou.edu/searchtools/.
I hope this helps. Thanks for asking.
To compare a normal and abnormal chromosome in the context of Alexander disease, we first need to understand the basics of chromosomes and the specific genetic abnormality associated with the condition.
Chromosomes are thread-like structures found in the nucleus of cells that carry genetic information in the form of genes. Humans typically have 46 chromosomes, arranged in pairs (23 pairs), with one set inherited from each parent.
Alexander disease is a rare genetic disorder that affects the central nervous system. It is caused by a mutation in a gene called GFAP (glial fibrillary acidic protein). This gene provides instructions for making a protein that is primarily found in cells called astrocytes, which support and nourish nerve cells in the brain.
In the case of Alexander disease, the abnormality lies in the genetic material (DNA) within the GFAP gene. This abnormality can be detected through genetic testing, such as DNA sequencing or chromosomal microarray analysis.
A comparison between a normal and abnormal chromosome in the context of Alexander disease would involve analyzing the specific region on the chromosome where the GFAP gene is located. In a person with Alexander disease, there may be a mutation or alteration in the DNA sequence of the GFAP gene, resulting in a non-functional protein or a protein with abnormal function.
It's important to note that Alexander disease is primarily caused by mutations in the GFAP gene, rather than changes in the structure or number of chromosomes themselves. Therefore, comparing normal and abnormal chromosomes in the context of Alexander disease would focus on the specific gene mutation rather than any observable differences in the overall chromosome structure.