You are a physiologist on a space flight to a distant planet. You discover aliens inhabiting the planet and they are willing to submit to your tests. You discover that the aliens kidney handles the sugar alcohol mannitol just like our kidneys handle inulin(not the same as insulin). You also test the alien for its renal handling of glucose. The dara is: Plasma level(constant over 24 hrs):6g/dL of mannitol and 2g/dL of glucose. 24 hr urine sample: volume of 2L, containing 144g mannitol and 52g glucose. What is the aliens GFR? What is the aliens clearance rate for glucose? How does the alien kidney handle glucose? I have struggled with this for hours now, any help will be appreciated!

Question

You are a physiologist on a space flight to a distant planet.  You discover aliens inhabiting the planet and they are willing to submit to your tests.  You discover that the aliens kidney handles the sugar alcohol mannitol just like our kidneys handle inulin(not the same as insulin).  You also test the alien for its renal handling of glucose.  The dara is:  Plasma level(constant over 24 hrs):6g/dL of mannitol and 2g/dL of glucose.  24 hr urine sample: volume of 2L, containing 144g mannitol and 52g glucose.  What is the aliens GFR?  What is the aliens clearance rate for glucose? How does the alien kidney handle glucose?  I have struggled with this for hours now, any help will be appreciated!

Camille · Answer

GFR= 4.2L/day Clearance= 48g