This article should get you started.
In addition to the very good Website from MsSue, here are others you might like:
1. (Wikipedia): http://en.wikipedia.org/wiki/Spanish_colonization_of_the_Americas
2. (part II of #1): http://en.wikipedia.org/wiki/South_American_Wars_of_Independence
3. (from NationMaster): http://www.nationmaster.com/encyclopedia/Slavery-in-the-Spanish-New-World-colonies
4. (from The Met Museum): http://www.metmuseum.org/toah/ht/08/canc/ht08canc.htm
5. (Jamaica): http://jamaica-guide.info/past.and.present/history/spanish.settlement/
6. (from Mediaman): http://www.mediaman.com.au/profiles/south_america.html
NOTE: Please post any other specific questions you may have.