Hemophilia is a hereditary disease that prevents a persons blood from clotting correct;y. The gene responsible for blood clotting is located on the X chromosome of the sex chromosome pair (X and Y. This is called x-linked inheritance. The dominant gene is H and the recessive causing hemophilia is h. Anyone with the dominant gene will not inherit hemophilia. Mother (X^h, X^H) and father (X^H and Y) have children X^H X^H, H^H X^h, X^H Y, and X^h Y. What are the chances of a child having hemophilia. WHy?

I looked at the diagram on wikipedia and it shows the exact same diagram that I have except the one on wikipedia is clearer. SO there would be a 75% chance that their children do not have hemophilia. Thank-you

• So the mother is normal XX The father is color blind XiY (the i indicates that the gene is affected) To be color blind and hemophiliac a woman needs to have XiXi and a man needs XiY This is both the same for color blindness and hemophilia. A woman can also be XiX. This would mean she is a carrier of the affected gene but not affected by the disease. Their daughters will all be carriers because only the X chromosome of the man is affected. This drawing explains it:

Fathermother
Theire daughter with genotype XXi marries a man with genotype XY (the daughter is carrier for both color blindness and hemophilia) If they get children they'll end up according to the next drawing:
femalemalemother father
So the chance that their son will have both the diseases is 50%
1 out of 4
50%

Based on the information provided, the chances of a child having hemophilia can be determined by analyzing the parents' genotypes.

The mother's genotype is X^h, X^H, which means that she is a carrier of the hemophilia gene but does not have hemophilia herself. The father's genotype is X^H, Y, indicating that he does not carry the hemophilia gene.

Let's analyze the possible genotypes of the children:

1. X^H, X^H: This child receives the dominant gene (H) from both parents and does not inherit hemophilia. They are not affected.

2. X^H, X^h: This child receives the dominant gene (H) from the mother and the recessive gene (h) from the father. They become a carrier of the hemophilia gene like the mother but do not have hemophilia themselves.

3. X^H, Y: This child receives the dominant gene (H) from the mother and the Y chromosome from the father. Since the Y chromosome does not contain the hemophilia gene, this child does not inherit hemophilia. They are not affected.

4. X^h, Y: This child receives the recessive gene (h) from the mother and the Y chromosome from the father. Since the recessive gene for hemophilia is present, this child will have hemophilia.

Therefore, out of the four possible combinations, the chances of a child having hemophilia are 1 out of 4, or 25%. This is because there is a 25% chance that the child will inherit the recessive hemophilia gene from the mother (X^h) and will not receive the dominant gene (H) from the father.

To determine the chances of a child having hemophilia in this scenario, we need to analyze the possible combinations of genes inherited from the parents.

Let's consider the different possibilities:

1. X^H X^H: This indicates a female child who inherited one copy of the dominant gene (X^H) from each parent. She does not have hemophilia because the dominant gene H will override the recessive gene h.

2. H^H X^h: This also represents a female child who inherited one copy of the dominant gene (H^H) from the father and one copy of the recessive gene (X^h) from the mother. She does not have hemophilia because the dominant gene H overrides the recessive gene h.

3. X^H Y: This refers to a male child who inherited the dominant gene (X^H) from the mother along with the Y chromosome from the father. As he only has one X chromosome, he will not have hemophilia because the dominant gene H will override any recessive gene h.

4. X^h Y: This represents a male child who inherited the recessive gene (X^h) from the mother and the Y chromosome from the father. Since he inherited the recessive gene from his mother, he will have hemophilia.

Considering the above possibilities, the chances of a child having hemophilia in this scenario would be 1 out of 4 (or 25%). This is because only one out of the four possible combinations results in the child inheriting the recessive gene for hemophilia (X^h Y).

It's important to note that this explanation assumes both parents are carriers of the hemophilia gene and that the inheritance follows traditional Mendelian genetics. In reality, various factors can influence the inheritance patterns, so it is always advisable to consult with a healthcare professional or genetic counselor for a comprehensive assessment.