If I said "The great American classic novel, The Adventures of Huckleberry Finn, written by Mark Twain and first published in 1884, is without a doubt...." would I put a comma after novel?

Yes -- so far you have the commas in the right places.

=)

Yes, you would put a comma after the word "novel" in this sentence. When introducing additional information or providing extra details about a noun, it is common to set off that information with commas. In this case, the phrase "written by Mark Twain and first published in 1884" is providing additional information about the novel, so it should be separated by commas. Therefore, the correct sentence would be:

"The great American classic novel, The Adventures of Huckleberry Finn, written by Mark Twain and first published in 1884, is without a doubt...."