How do enzymes reduce the energy of activation of biochemical reactions?

Enzymes provide an alternate mechanism for bonding/unbonding, thus lowering the energy required.

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describe how the hypothalamus, posterior pituitary, and the distal tubule would respond to control the solute concentration of the blood

To understand how the hypothalamus, posterior pituitary, and distal tubules respond to control the solute concentration of the blood, you can follow these steps:

1. Start by gaining a basic understanding of the functions of each of these components:
- The hypothalamus is a region in the brain that plays a crucial role in the regulation of various bodily functions, including the secretion of hormones.
- The posterior pituitary is an extension of the hypothalamus and stores and releases two important hormones, oxytocin and antidiuretic hormone (ADH), into the bloodstream.
- The distal tubules are part of the kidney's nephron, which helps in the regulation of water and electrolyte balance in the body.

2. Research how the hypothalamus regulates solute concentration in the blood:
- The hypothalamus detects changes in the solute concentration of the blood through specialized cells called osmoreceptors.
- If the solute concentration is too high, the osmoreceptors in the hypothalamus stimulate the release of ADH from the posterior pituitary.

3. Investigate the role of ADH in controlling solute concentration:
- ADH, also known as vasopressin, acts on the distal tubules in the kidney.
- It increases the permeability of the distal tubules, allowing more water reabsorption.
- As a result, less water is lost in urine, leading to concentrated urine and preventing further solute concentration in the blood.

4. Understand the feedback loop in solute concentration regulation:
- If the solute concentration of the blood decreases, the osmoreceptors in the hypothalamus reduce the release of ADH.
- This, in turn, decreases water reabsorption in the distal tubules, allowing more water to be excreted in urine.
- This helps to restore the solute concentration to normal levels.

By following these steps, you should be able to understand how the hypothalamus, posterior pituitary, and distal tubules respond to control the solute concentration of the blood.